276414

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 9288..9876 Replicon plasmid pII_RAB9
Accession NZ_CP121558
Organism Acinetobacter baumannii strain RAB9

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag MTS96_RS18565 Protein ID WP_000438826.1
Coordinates 9288..9575 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag MTS96_RS18570 Protein ID WP_001983304.1
Coordinates 9562..9876 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTS96_RS18535 (MTS96_18535) 4773..4946 - 174 WP_001282484.1 hypothetical protein -
MTS96_RS18540 (MTS96_18540) 4946..5317 - 372 WP_000504218.1 hypothetical protein -
MTS96_RS18545 (MTS96_18545) 6527..7477 + 951 WP_001205343.1 replication initiation protein RepM -
MTS96_RS18550 (MTS96_18550) 7470..8045 + 576 WP_243327585.1 plasmid replication DNA-binding protein -
MTS96_RS18555 (MTS96_18555) 8065..8208 + 144 WP_001125246.1 hypothetical protein -
MTS96_RS18560 (MTS96_18560) 8397..8915 - 519 WP_000447193.1 tetratricopeptide repeat protein -
MTS96_RS18565 (MTS96_18565) 9288..9575 + 288 WP_000438826.1 BrnT family toxin Toxin
MTS96_RS18570 (MTS96_18570) 9562..9876 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
MTS96_RS18575 (MTS96_18575) 10004..12415 + 2412 Protein_13 TonB-dependent receptor ZnuD2 -
MTS96_RS18580 (MTS96_18580) 12720..13181 + 462 WP_000761346.1 DIP1984 family protein -
MTS96_RS18585 (MTS96_18585) 13504..13677 - 174 WP_001282484.1 hypothetical protein -
MTS96_RS18590 (MTS96_18590) 13677..14048 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..17462 17462


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T276414 WP_000438826.1 NZ_CP121558:9288-9575 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT276414 WP_001983304.1 NZ_CP121558:9562-9876 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References