Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1149499..1150301 Replicon chromosome
Accession NZ_CP121529
Organism Staphylococcus epidermidis strain 1FSE03

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag QA592_RS05470 Protein ID WP_002468490.1
Coordinates 1150122..1150301 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag QA592_RS05465 Protein ID WP_002456349.1
Coordinates 1149499..1150098 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA592_RS05440 1144600..1145322 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
QA592_RS05445 1145800..1146999 + 1200 WP_071813246.1 IS110-like element ISSep2 family transposase -
QA592_RS05450 1147379..1147534 + 156 WP_001829854.1 hypothetical protein -
QA592_RS05455 1147744..1148874 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
QA592_RS05460 1148871..1149341 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QA592_RS05465 1149499..1150098 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
QA592_RS05470 1150122..1150301 + 180 WP_002468490.1 SAS053 family protein Toxin
QA592_RS05475 1150457..1150861 + 405 WP_001829818.1 hypothetical protein -
QA592_RS05480 1151046..1152431 + 1386 WP_001829862.1 class II fumarate hydratase -
QA592_RS05485 1152792..1153616 - 825 WP_001829804.1 RluA family pseudouridine synthase -
QA592_RS05490 1153775..1154908 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T276410 WP_002468490.1 NZ_CP121529:1150122-1150301 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT276410 WP_002456349.1 NZ_CP121529:1149499-1150098 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References