Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 249318..250120 Replicon chromosome
Accession NZ_CP121527
Organism Staphylococcus epidermidis strain 1FSE01

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag QA586_RS01400 Protein ID WP_002468490.1
Coordinates 249941..250120 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag QA586_RS01395 Protein ID WP_002486232.1
Coordinates 249318..249917 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA586_RS01370 244530..245987 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
QA586_RS01375 245980..246702 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
QA586_RS01380 247217..247348 + 132 WP_255264851.1 hypothetical protein -
QA586_RS01385 247563..248693 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
QA586_RS01390 248690..249160 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QA586_RS01395 249318..249917 + 600 WP_002486232.1 glucosamine-6-phosphate isomerase Antitoxin
QA586_RS01400 249941..250120 + 180 WP_002468490.1 SAS053 family protein Toxin
QA586_RS01405 250276..250680 + 405 WP_002485605.1 hypothetical protein -
QA586_RS01410 250865..252250 + 1386 WP_001829862.1 class II fumarate hydratase -
QA586_RS01415 252611..253435 - 825 WP_001829804.1 RluA family pseudouridine synthase -
QA586_RS01420 253594..254727 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T276406 WP_002468490.1 NZ_CP121527:249941-250120 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22695.55 Da        Isoelectric Point: 4.8641

>AT276406 WP_002486232.1 NZ_CP121527:249318-249917 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGNLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure

References