276402

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1484873..1485402 Replicon chromosome
Accession NZ_CP121526
Organism Staphylococcus epidermidis strain 1FSE05

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag QA624_RS08700 Protein ID WP_001829891.1
Coordinates 1484873..1485235 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag QA624_RS08705 Protein ID WP_001829931.1
Coordinates 1485232..1485402 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA624_RS08680 1481881..1482651 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
QA624_RS08685 1482626..1483099 - 474 WP_002469585.1 anti-sigma B factor RsbW -
QA624_RS08690 1483101..1483427 - 327 WP_001829952.1 anti-sigma factor antagonist -
QA624_RS08695 1483527..1484528 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
QA624_RS08700 1484873..1485235 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QA624_RS08705 1485232..1485402 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QA624_RS08710 1485489..1486637 - 1149 WP_002457107.1 alanine racemase -
QA624_RS08715 1486704..1487057 - 354 WP_002457108.1 holo-ACP synthase -
QA624_RS08720 1487105..1487613 - 509 Protein_1353 PH domain-containing protein -
QA624_RS08725 1487600..1489104 - 1505 Protein_1354 PH domain-containing protein -
QA624_RS08730 1489097..1489576 - 480 WP_002469586.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T276402 WP_001829891.1 NZ_CP121526:c1485235-1484873 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT276402 WP_001829931.1 NZ_CP121526:c1485402-1485232 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References