Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 11895..12424 Replicon chromosome
Accession NZ_CP121518
Organism Staphylococcus epidermidis strain 6DSE07

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag QA594_RS00060 Protein ID WP_001829891.1
Coordinates 11895..12257 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag QA594_RS00065 Protein ID WP_001829931.1
Coordinates 12254..12424 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA594_RS00040 8897..9667 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
QA594_RS00045 9642..10121 - 480 WP_001829903.1 anti-sigma B factor RsbW -
QA594_RS00050 10123..10449 - 327 WP_001829952.1 anti-sigma factor antagonist -
QA594_RS00055 10549..11550 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
QA594_RS00060 11895..12257 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QA594_RS00065 12254..12424 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QA594_RS00070 12511..13659 - 1149 WP_002457107.1 alanine racemase -
QA594_RS00075 13726..14079 - 354 WP_002457108.1 holo-ACP synthase -
QA594_RS00080 14127..14636 - 510 WP_002457109.1 PH domain-containing protein -
QA594_RS00085 14623..16128 - 1506 WP_002457110.1 PH domain-containing protein -
QA594_RS00090 16121..16600 - 480 WP_010959254.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T276392 WP_001829891.1 NZ_CP121518:c12257-11895 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT276392 WP_001829931.1 NZ_CP121518:c12424-12254 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References