276386

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1893130..1893639 Replicon chromosome
Accession NZ_CP121509
Organism Staphylococcus epidermidis strain 21FSE01

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag QA595_RS08805 Protein ID WP_001829980.1
Coordinates 1893130..1893339 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag QA595_RS08810 Protein ID WP_001829893.1
Coordinates 1893346..1893639 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA595_RS08785 1888709..1890064 - 1356 WP_032606414.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
QA595_RS08790 1890076..1891149 - 1074 WP_257756224.1 D-alanine--D-alanine ligase -
QA595_RS08795 1891540..1892751 + 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
QA595_RS08800 1892850..1892987 - 138 WP_001829949.1 Lmo0850 family protein -
QA595_RS08805 1893130..1893339 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
QA595_RS08810 1893346..1893639 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
QA595_RS08815 1893813..1895297 + 1485 WP_002457116.1 cardiolipin synthase -
QA595_RS08820 1895479..1896132 + 654 WP_001829983.1 HD domain-containing protein -
QA595_RS08825 1896238..1897110 - 873 WP_002458703.1 membrane protein insertase YidC -
QA595_RS08830 1897199..1897837 - 639 WP_002505076.1 thiamine phosphate synthase -
QA595_RS08835 1897843..1898631 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec - groEL 1789341..2086436 297095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T276386 WP_001829980.1 NZ_CP121509:c1893339-1893130 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT276386 WP_001829893.1 NZ_CP121509:c1893639-1893346 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References