276385

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1881925..1882454 Replicon chromosome
Accession NZ_CP121509
Organism Staphylococcus epidermidis strain 21FSE01

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag QA595_RS08745 Protein ID WP_001829891.1
Coordinates 1881925..1882287 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag QA595_RS08750 Protein ID WP_001829931.1
Coordinates 1882284..1882454 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA595_RS08725 1878927..1879697 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
QA595_RS08730 1879672..1880151 - 480 WP_001829903.1 anti-sigma B factor RsbW -
QA595_RS08735 1880153..1880479 - 327 WP_001829952.1 anti-sigma factor antagonist -
QA595_RS08740 1880579..1881580 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
QA595_RS08745 1881925..1882287 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QA595_RS08750 1882284..1882454 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QA595_RS08755 1882541..1883689 - 1149 WP_002457107.1 alanine racemase -
QA595_RS08760 1883756..1884109 - 354 WP_002457108.1 holo-ACP synthase -
QA595_RS08765 1884157..1884666 - 510 WP_002457109.1 PH domain-containing protein -
QA595_RS08770 1884653..1886158 - 1506 WP_002457110.1 PH domain-containing protein -
QA595_RS08775 1886151..1886630 - 480 WP_002457111.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec - groEL 1789341..2086436 297095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T276385 WP_001829891.1 NZ_CP121509:c1882287-1881925 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT276385 WP_001829931.1 NZ_CP121509:c1882454-1882284 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References