276381

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1091204..1091733 Replicon chromosome
Accession NZ_CP121507
Organism Staphylococcus epidermidis strain 23DSE01

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag QA588_RS05050 Protein ID WP_001829891.1
Coordinates 1091371..1091733 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag QA588_RS05045 Protein ID WP_001829931.1
Coordinates 1091204..1091374 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA588_RS05020 1087028..1087507 + 480 WP_002469586.1 PH domain-containing protein -
QA588_RS05025 1087500..1089005 + 1506 WP_002457110.1 PH domain-containing protein -
QA588_RS05030 1088992..1089501 + 510 WP_002457109.1 PH domain-containing protein -
QA588_RS05035 1089549..1089902 + 354 WP_002457108.1 holo-ACP synthase -
QA588_RS05040 1089969..1091117 + 1149 WP_002457107.1 alanine racemase -
QA588_RS05045 1091204..1091374 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QA588_RS05050 1091371..1091733 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QA588_RS05055 1092078..1093079 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
QA588_RS05060 1093179..1093505 + 327 WP_001829952.1 anti-sigma factor antagonist -
QA588_RS05065 1093507..1093980 + 474 WP_002469585.1 anti-sigma B factor RsbW -
QA588_RS05070 1093955..1094725 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T276381 WP_001829891.1 NZ_CP121507:1091371-1091733 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT276381 WP_001829931.1 NZ_CP121507:1091204-1091374 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References