Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1080018..1080527 Replicon chromosome
Accession NZ_CP121507
Organism Staphylococcus epidermidis strain 23DSE01

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag QA588_RS04990 Protein ID WP_001829980.1
Coordinates 1080318..1080527 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag QA588_RS04985 Protein ID WP_001829893.1
Coordinates 1080018..1080311 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA588_RS04960 1075026..1075814 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
QA588_RS04965 1075820..1076458 + 639 WP_002505076.1 thiamine phosphate synthase -
QA588_RS04970 1076547..1077419 + 873 WP_002470121.1 membrane protein insertase YidC -
QA588_RS04975 1077525..1078178 - 654 WP_001829983.1 HD domain-containing protein -
QA588_RS04980 1078360..1079844 - 1485 WP_002457116.1 cardiolipin synthase -
QA588_RS04985 1080018..1080311 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
QA588_RS04990 1080318..1080527 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
QA588_RS04995 1080670..1080807 + 138 WP_001829949.1 Lmo0850 family protein -
QA588_RS05000 1080906..1082117 - 1212 WP_002457115.1 FtsW/RodA/SpoVE family cell cycle protein -
QA588_RS05005 1082508..1083581 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
QA588_RS05010 1083593..1084948 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T276380 WP_001829980.1 NZ_CP121507:1080318-1080527 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T276380 NZ_CP121507:1080318-1080527 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT276380 WP_001829893.1 NZ_CP121507:1080018-1080311 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT276380 NZ_CP121507:1080018-1080311 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References