276378

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1429152..1429681 Replicon chromosome
Accession NZ_CP121502
Organism Staphylococcus epidermidis strain 24FSE01

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag QA608_RS06845 Protein ID WP_001829891.1
Coordinates 1429152..1429514 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag QA608_RS06850 Protein ID WP_001829931.1
Coordinates 1429511..1429681 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA608_RS06825 1426153..1426923 - 771 WP_002468952.1 RNA polymerase sigma factor SigB -
QA608_RS06830 1426898..1427377 - 480 WP_001829903.1 anti-sigma B factor RsbW -
QA608_RS06835 1427379..1427705 - 327 WP_001829952.1 anti-sigma factor antagonist -
QA608_RS06840 1427805..1428806 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
QA608_RS06845 1429152..1429514 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QA608_RS06850 1429511..1429681 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QA608_RS06855 1429768..1430916 - 1149 WP_002468951.1 alanine racemase -
QA608_RS06860 1430982..1431335 - 354 WP_001829915.1 holo-ACP synthase -
QA608_RS06865 1431383..1431892 - 510 WP_001829888.1 PH domain-containing protein -
QA608_RS06870 1431879..1433384 - 1506 WP_001829976.1 PH domain-containing protein -
QA608_RS06875 1433377..1433856 - 480 WP_278270020.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T276378 WP_001829891.1 NZ_CP121502:c1429514-1429152 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT276378 WP_001829931.1 NZ_CP121502:c1429681-1429511 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References