Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1264255..1265057 Replicon chromosome
Accession NZ_CP121502
Organism Staphylococcus epidermidis strain 24FSE01

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag QA608_RS05900 Protein ID WP_002468490.1
Coordinates 1264255..1264434 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag QA608_RS05905 Protein ID WP_002456349.1
Coordinates 1264458..1265057 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA608_RS05880 1259648..1260781 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
QA608_RS05885 1260940..1261764 + 825 WP_001829804.1 RluA family pseudouridine synthase -
QA608_RS05890 1262125..1263510 - 1386 WP_278270077.1 class II fumarate hydratase -
QA608_RS05895 1263695..1264099 - 405 WP_001829818.1 hypothetical protein -
QA608_RS05900 1264255..1264434 - 180 WP_002468490.1 SAS053 family protein Toxin
QA608_RS05905 1264458..1265057 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
QA608_RS05910 1265215..1265685 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QA608_RS05915 1265682..1266812 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
QA608_RS05920 1267022..1267159 - 138 WP_064783702.1 hypothetical protein -
QA608_RS05925 1267674..1268396 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
QA608_RS05930 1268389..1269846 - 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T276377 WP_002468490.1 NZ_CP121502:c1264434-1264255 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT276377 WP_002456349.1 NZ_CP121502:c1265057-1264458 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References