Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1141602..1142404 Replicon chromosome
Accession NZ_CP121497
Organism Staphylococcus epidermidis strain 24FSE04

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag QA611_RS05540 Protein ID WP_002468490.1
Coordinates 1142225..1142404 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag QA611_RS05535 Protein ID WP_002456349.1
Coordinates 1141602..1142201 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA611_RS05510 1136813..1138270 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
QA611_RS05515 1138263..1138985 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
QA611_RS05520 1139500..1139637 + 138 WP_064783702.1 hypothetical protein -
QA611_RS05525 1139847..1140977 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
QA611_RS05530 1140974..1141444 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QA611_RS05535 1141602..1142201 + 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
QA611_RS05540 1142225..1142404 + 180 WP_002468490.1 SAS053 family protein Toxin
QA611_RS05545 1142560..1142964 + 405 WP_001829818.1 hypothetical protein -
QA611_RS05550 1143149..1144534 + 1386 WP_278270077.1 class II fumarate hydratase -
QA611_RS05555 1144895..1145719 - 825 WP_001829804.1 RluA family pseudouridine synthase -
QA611_RS05560 1145878..1147011 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T276374 WP_002468490.1 NZ_CP121497:1142225-1142404 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT276374 WP_002456349.1 NZ_CP121497:1141602-1142201 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References