276373

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 976974..977503 Replicon chromosome
Accession NZ_CP121497
Organism Staphylococcus epidermidis strain 24FSE04

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag QA611_RS04595 Protein ID WP_001829891.1
Coordinates 977141..977503 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag QA611_RS04590 Protein ID WP_001829931.1
Coordinates 976974..977144 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA611_RS04565 972799..973278 + 480 WP_278270020.1 PH domain-containing protein -
QA611_RS04570 973271..974776 + 1506 WP_001829976.1 PH domain-containing protein -
QA611_RS04575 974763..975272 + 510 WP_001829888.1 PH domain-containing protein -
QA611_RS04580 975320..975673 + 354 WP_001829915.1 holo-ACP synthase -
QA611_RS04585 975739..976887 + 1149 WP_002468951.1 alanine racemase -
QA611_RS04590 976974..977144 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QA611_RS04595 977141..977503 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QA611_RS04600 977849..978850 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
QA611_RS04605 978950..979276 + 327 WP_001829952.1 anti-sigma factor antagonist -
QA611_RS04610 979278..979757 + 480 WP_001829903.1 anti-sigma B factor RsbW -
QA611_RS04615 979732..980502 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T276373 WP_001829891.1 NZ_CP121497:977141-977503 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT276373 WP_001829931.1 NZ_CP121497:976974-977144 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References