Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2494321..2494850 Replicon chromosome
Accession NZ_CP121483
Organism Staphylococcus epidermidis strain 32FSE07

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag QA590_RS11650 Protein ID WP_001829891.1
Coordinates 2494488..2494850 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag QA590_RS11645 Protein ID WP_001829931.1
Coordinates 2494321..2494491 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA590_RS11620 2490145..2490624 + 480 WP_002457111.1 PH domain-containing protein -
QA590_RS11625 2490617..2492122 + 1506 WP_002457110.1 PH domain-containing protein -
QA590_RS11630 2492109..2492618 + 510 WP_002457109.1 PH domain-containing protein -
QA590_RS11635 2492666..2493019 + 354 WP_049376678.1 holo-ACP synthase -
QA590_RS11640 2493086..2494234 + 1149 WP_002457107.1 alanine racemase -
QA590_RS11645 2494321..2494491 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QA590_RS11650 2494488..2494850 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QA590_RS11655 2495195..2496196 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
QA590_RS11660 2496296..2496622 + 327 WP_001829952.1 anti-sigma factor antagonist -
QA590_RS11665 2496624..2497103 + 480 WP_001829903.1 anti-sigma B factor RsbW -
QA590_RS11670 2497078..2497848 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2488487..2489560 1073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T276365 WP_001829891.1 NZ_CP121483:2494488-2494850 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT276365 WP_001829931.1 NZ_CP121483:2494321-2494491 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References