Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2481576..2482085 Replicon chromosome
Accession NZ_CP121483
Organism Staphylococcus epidermidis strain 32FSE07

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag QA590_RS11585 Protein ID WP_001829980.1
Coordinates 2481876..2482085 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag QA590_RS11580 Protein ID WP_001829893.1
Coordinates 2481576..2481869 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA590_RS11555 2476605..2477393 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
QA590_RS11560 2477399..2478037 + 639 WP_002505076.1 thiamine phosphate synthase -
QA590_RS11565 2478126..2478998 + 873 WP_002458703.1 membrane protein insertase YidC -
QA590_RS11570 2479104..2479757 - 654 WP_001829983.1 HD domain-containing protein -
QA590_RS11575 2479918..2481402 - 1485 WP_002457116.1 cardiolipin synthase -
QA590_RS11580 2481576..2481869 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
QA590_RS11585 2481876..2482085 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
QA590_RS11590 2482228..2482365 + 138 WP_001829949.1 Lmo0850 family protein -
QA590_RS11595 2482464..2483675 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
QA590_RS11600 2484066..2485139 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
QA590_RS11605 2485151..2486506 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T276364 WP_001829980.1 NZ_CP121483:2481876-2482085 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT276364 WP_001829893.1 NZ_CP121483:2481576-2481869 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References