276361

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2463862..2464391 Replicon chromosome
Accession NZ_CP121480
Organism Staphylococcus epidermidis strain 47FSE01

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag QA589_RS11695 Protein ID WP_001829891.1
Coordinates 2464029..2464391 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag QA589_RS11690 Protein ID WP_001829931.1
Coordinates 2463862..2464032 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA589_RS11665 2459686..2460165 + 480 WP_010959254.1 PH domain-containing protein -
QA589_RS11670 2460158..2461663 + 1506 WP_002457110.1 PH domain-containing protein -
QA589_RS11675 2461650..2462159 + 510 WP_002457109.1 PH domain-containing protein -
QA589_RS11680 2462207..2462560 + 354 WP_002457108.1 holo-ACP synthase -
QA589_RS11685 2462627..2463775 + 1149 WP_002457107.1 alanine racemase -
QA589_RS11690 2463862..2464032 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QA589_RS11695 2464029..2464391 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QA589_RS11700 2464736..2465737 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
QA589_RS11705 2465837..2466163 + 327 WP_001829952.1 anti-sigma factor antagonist -
QA589_RS11710 2466165..2466644 + 480 WP_001829903.1 anti-sigma B factor RsbW -
QA589_RS11715 2466619..2467389 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T276361 WP_001829891.1 NZ_CP121480:2464029-2464391 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT276361 WP_001829931.1 NZ_CP121480:2463862-2464032 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References