Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2452677..2453186 Replicon chromosome
Accession NZ_CP121480
Organism Staphylococcus epidermidis strain 47FSE01

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag QA589_RS11635 Protein ID WP_001829980.1
Coordinates 2452977..2453186 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag QA589_RS11630 Protein ID WP_001829893.1
Coordinates 2452677..2452970 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QA589_RS11605 2447685..2448473 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
QA589_RS11610 2448479..2449117 + 639 WP_002505076.1 thiamine phosphate synthase -
QA589_RS11615 2449206..2450078 + 873 WP_002458703.1 membrane protein insertase YidC -
QA589_RS11620 2450184..2450837 - 654 WP_001829983.1 HD domain-containing protein -
QA589_RS11625 2451019..2452503 - 1485 WP_002457116.1 cardiolipin synthase -
QA589_RS11630 2452677..2452970 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
QA589_RS11635 2452977..2453186 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
QA589_RS11640 2453329..2453466 + 138 WP_001829949.1 Lmo0850 family protein -
QA589_RS11645 2453607..2454776 - 1170 WP_278269553.1 FtsW/RodA/SpoVE family cell cycle protein -
QA589_RS11650 2455167..2456240 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
QA589_RS11655 2456252..2457607 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T276360 WP_001829980.1 NZ_CP121480:2452977-2453186 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT276360 WP_001829893.1 NZ_CP121480:2452677-2452970 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References