276351

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2752114..2753709 Replicon chromosome
Accession NZ_CP121476
Organism Pseudomonas sp. 905_Psudmo1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P9K38_RS12930 Protein ID WP_278324786.1
Coordinates 2752384..2753709 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1G5YAZ4
Locus tag P9K38_RS12925 Protein ID WP_017676963.1
Coordinates 2752114..2752383 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9K38_RS12920 (P9K38_12920) 2750609..2751673 + 1065 WP_278324784.1 type VI secretion system protein TssA -
P9K38_RS12925 (P9K38_12925) 2752114..2752383 - 270 WP_017676963.1 helix-turn-helix domain-containing protein Antitoxin
P9K38_RS12930 (P9K38_12930) 2752384..2753709 - 1326 WP_278324786.1 HipA domain-containing protein Toxin
P9K38_RS12935 (P9K38_12935) 2753965..2754171 + 207 WP_278326890.1 hypothetical protein -
P9K38_RS12940 (P9K38_12940) 2754280..2755422 + 1143 WP_278324787.1 elongation factor P maturation arginine rhamnosyltransferase EarP -
P9K38_RS12945 (P9K38_12945) 2755457..2756029 + 573 WP_003460252.1 elongation factor P -
P9K38_RS12950 (P9K38_12950) 2756129..2757091 - 963 WP_039964599.1 LysR family transcriptional regulator -
P9K38_RS12955 (P9K38_12955) 2757192..2757959 + 768 WP_064494771.1 sulfite exporter TauE/SafE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-380)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49158.53 Da        Isoelectric Point: 5.8080

>T276351 WP_278324786.1 NZ_CP121476:c2753709-2752384 [Pseudomonas sp. 905_Psudmo1]
MHSLTLQLYSGHAWHDAMHLNFEQPEAGLAGSCSFGYEQAYLLETLEHIGSRLEHAVSVTVPLDWESYRASEAPAFLHDI
LPAGAARRFLIQRLGDQKPENLGLDLFLLSRCAPAPVGNLRIKEAAAALQESPLLGFSREDVINRDARFLEYAYEQGAAI
GGATGAGGEAPKLLLTEDREGALHPDAALPDESATRHWFVKFARNQARQTDQDILRSEFCYYRAIQRLGLDTVPAEGLAL
EEGRKPSLWMHRFDRHLSAAGVERSAMESLYSLAGVTVPGSYLLHTDVLHHLVRLWQKTGQGAQVGDMIFEYLQRDLLNQ
ILGNSDNHGRNTSILRNSTGLKLAPIYDLAPMVMDDEGVTRTTKWPQSIEIAGEVNWRQACAALAQWTDADVLYERLRGS
AQDFLALPDLLSDQGLPNSTMNHPRIALRTLHQRLNRWELV

Download         Length: 1326 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10104.75 Da        Isoelectric Point: 10.7429

>AT276351 WP_017676963.1 NZ_CP121476:c2752383-2752114 [Pseudomonas sp. 905_Psudmo1]
MDIIERNRILTEIQTQLASGELTIGQAVRKLRKEITGLQQARFAQMCKLSLRALRQLEHDESNPTVQTLNSVFNPFGMQV
GIVPKSRIQ

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1G5YAZ4

References