276349

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1234600..1235517 Replicon chromosome
Accession NZ_CP121465
Organism Bacillus velezensis strain YA215

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag P9972_RS06480 Protein ID WP_025851786.1
Coordinates 1234771..1235517 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag P9972_RS06475 Protein ID WP_003154807.1
Coordinates 1234600..1234770 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9972_RS06435 (P9972_06435) 1229831..1231453 + 1623 WP_014304855.1 pyocin knob domain-containing protein -
P9972_RS06440 (P9972_06440) 1231466..1231774 + 309 WP_224979391.1 hypothetical protein -
P9972_RS06445 (P9972_06445) 1231843..1232040 + 198 WP_003154819.1 XkdX family protein -
P9972_RS06450 (P9972_06450) 1232097..1232858 + 762 WP_043867020.1 hypothetical protein -
P9972_RS06455 (P9972_06455) 1232910..1233173 + 264 WP_003154815.1 hemolysin XhlA family protein -
P9972_RS06460 (P9972_06460) 1233187..1233450 + 264 WP_003154813.1 phage holin -
P9972_RS06465 (P9972_06465) 1233464..1234342 + 879 WP_024085195.1 N-acetylmuramoyl-L-alanine amidase -
P9972_RS06470 (P9972_06470) 1234378..1234503 - 126 WP_003154809.1 hypothetical protein -
P9972_RS06475 (P9972_06475) 1234600..1234770 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
P9972_RS06480 (P9972_06480) 1234771..1235517 - 747 WP_025851786.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
P9972_RS06485 (P9972_06485) 1235621..1236619 - 999 WP_003154805.1 inorganic phosphate transporter -
P9972_RS06490 (P9972_06490) 1236632..1237249 - 618 WP_003154804.1 DUF47 domain-containing protein -
P9972_RS06495 (P9972_06495) 1237535..1238851 - 1317 WP_003154801.1 amino acid permease -
P9972_RS06500 (P9972_06500) 1239174..1240124 + 951 WP_043867021.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29048.53 Da        Isoelectric Point: 4.7003

>T276349 WP_025851786.1 NZ_CP121465:c1235517-1234771 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CEYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT276349 WP_003154807.1 NZ_CP121465:c1234770-1234600 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References