Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) AbkB-brnA/BrnT-BrnA
Location 14651..15239 Replicon plasmid plas4_LRT
Accession NZ_CP121379
Organism Acinetobacter baumannii strain LRT

Toxin (Protein)


Gene name AbkB Uniprot ID -
Locus tag P9J63_RS19490 Protein ID WP_278221572.1
Coordinates 14952..15239 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A0U3TC92
Locus tag P9J63_RS19485 Protein ID WP_032038670.1
Coordinates 14651..14965 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9J63_RS19460 (P9J63_19460) 11087..11581 - 495 WP_005175503.1 MobC family plasmid mobilization relaxosome protein -
P9J63_RS19465 (P9J63_19465) 11952..12197 - 246 WP_109292003.1 hypothetical protein -
P9J63_RS19470 (P9J63_19470) 12346..12570 + 225 WP_005401979.1 hypothetical protein -
P9J63_RS19475 (P9J63_19475) 12729..13892 + 1164 WP_068553174.1 ATP-binding protein -
P9J63_RS19480 (P9J63_19480) 13889..14578 + 690 WP_068553176.1 hypothetical protein -
P9J63_RS19485 (P9J63_19485) 14651..14965 - 315 WP_032038670.1 BrnA antitoxin family protein Antitoxin
P9J63_RS19490 (P9J63_19490) 14952..15239 - 288 WP_278221572.1 BrnT family toxin Toxin
P9J63_RS19495 (P9J63_19495) 15468..15851 - 384 WP_270901924.1 hypothetical protein -
P9J63_RS19500 (P9J63_19500) 16483..17144 + 662 Protein_14 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..40316 40316
- flank IS/Tn - - 16567..17097 530


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11261.72 Da        Isoelectric Point: 6.4846

>T276340 WP_278221572.1 NZ_CP121379:c15239-14952 [Acinetobacter baumannii]
MKQYFEWDEAKNRKNQKKHDVSFETASLVFEDPLRISIQDRHTDGEERWQTIGKVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12269.00 Da        Isoelectric Point: 9.4646

>AT276340 WP_032038670.1 NZ_CP121379:c14965-14651 [Acinetobacter baumannii]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDMPEITDWSNAVRHNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKKHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3TC92

References