Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 15916..16504 Replicon plasmid plas1_LRT
Accession NZ_CP121376
Organism Acinetobacter baumannii strain LRT

Toxin (Protein)


Gene name relE Uniprot ID A0A5K1MH32
Locus tag P9J63_RS18325 Protein ID WP_000569859.1
Coordinates 16208..16504 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag P9J63_RS18320 Protein ID WP_000241337.1
Coordinates 15916..16206 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9J63_RS18300 (P9J63_18300) 11665..12663 + 999 WP_004740250.1 zinc-binding alcohol dehydrogenase family protein -
P9J63_RS18305 (P9J63_18305) 12684..12968 + 285 WP_000156168.1 putative quinol monooxygenase -
P9J63_RS18310 (P9J63_18310) 13032..14255 - 1224 WP_123794025.1 IS256 family transposase -
P9J63_RS18320 (P9J63_18320) 15916..16206 - 291 WP_000241337.1 putative addiction module antidote protein Antitoxin
P9J63_RS18325 (P9J63_18325) 16208..16504 - 297 WP_000569859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9J63_RS18330 (P9J63_18330) 16841..18175 - 1335 WP_032050497.1 ISNCY family transposase -
P9J63_RS18335 (P9J63_18335) 18320..19225 - 906 WP_005130397.1 aromatic amino acid DMT transporter YddG -
P9J63_RS18340 (P9J63_18340) 19238..20530 - 1293 WP_024436605.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..101824 101824
- inside IScluster/Tn - - 13032..18163 5131


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11554.35 Da        Isoelectric Point: 8.5037

>T276338 WP_000569859.1 NZ_CP121376:c16504-16208 [Acinetobacter baumannii]
MIEIKRLPEFDEWLDGLKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGAGWRMYYIQHGDVVIVMLGGGEKS
TQKDDIKKAVKLSKTLED

Download         Length: 297 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10584.24 Da        Isoelectric Point: 5.1133

>AT276338 WP_000241337.1 NZ_CP121376:c16206-15916 [Acinetobacter baumannii]
MVKVADLPSFDMAESLKTEEDIVMYLNMVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSTPRFDTI
NRVVNALGLKLTVQHT

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5K1MH32

Antitoxin

Source ID Structure

References