Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 15916..16504 Replicon plasmid plas1_LRT
Accession NZ_CP121376
Organism Acinetobacter baumannii strain LRT

Toxin (Protein)


Gene name relE Uniprot ID A0A5K1MH32
Locus tag P9J63_RS18325 Protein ID WP_000569859.1
Coordinates 16208..16504 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag P9J63_RS18320 Protein ID WP_000241337.1
Coordinates 15916..16206 (-) Length 97 a.a.

Genomic Context

P9J63_RS18300P9J63_RS18305P9J63_RS18310P9J63_RS18320P9J63_RS18325P9J63_RS18330P9J63_RS18335P9J63_RS18340
Location: 11665..12663 (999 bp)
Type: Others
Protein ID: WP_004740250.1
Location: 12684..12968 (285 bp)
Type: Others
Protein ID: WP_000156168.1
Location: 13032..14255 (1224 bp)
Type: Others
Protein ID: WP_123794025.1
Location: 15916..16206 (291 bp)
Type: Antitoxin
Protein ID: WP_000241337.1
Location: 16208..16504 (297 bp)
Type: Toxin
Protein ID: WP_000569859.1
Location: 16841..18175 (1335 bp)
Type: Others
Protein ID: WP_032050497.1
Location: 18320..19225 (906 bp)
Type: Others
Protein ID: WP_005130397.1
Location: 19238..20530 (1293 bp)
Type: Others
Protein ID: WP_024436605.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
P9J63_RS18300 (P9J63_18300)11665..12663+999WP_004740250.1zinc-binding alcohol dehydrogenase family protein-
P9J63_RS18305 (P9J63_18305)12684..12968+285WP_000156168.1putative quinol monooxygenase-
P9J63_RS18310 (P9J63_18310)13032..14255-1224WP_123794025.1IS256 family transposase-
P9J63_RS18320 (P9J63_18320)15916..16206-291WP_000241337.1putative addiction module antidote proteinAntitoxin
P9J63_RS18325 (P9J63_18325)16208..16504-297WP_000569859.1type II toxin-antitoxin system RelE/ParE family toxinToxin
P9J63_RS18330 (P9J63_18330)16841..18175-1335WP_032050497.1ISNCY family transposase-
P9J63_RS18335 (P9J63_18335)18320..19225-906WP_005130397.1aromatic amino acid DMT transporter YddG-
P9J63_RS18340 (P9J63_18340)19238..20530-1293WP_024436605.1MFS transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..101824101824
-insideIScluster/Tn--13032..181635131


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11554.35 Da        Isoelectric Point: 8.5037

>T276338 WP_000569859.1 NZ_CP121376:c16504-16208 [Acinetobacter baumannii]
MIEIKRLPEFDEWLDGLKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGAGWRMYYIQHGDVVIVMLGGGEKS
TQKDDIKKAVKLSKTLED

Download         Length: 297 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10584.24 Da        Isoelectric Point: 5.1133

>AT276338 WP_000241337.1 NZ_CP121376:c16206-15916 [Acinetobacter baumannii]
MVKVADLPSFDMAESLKTEEDIVMYLNMVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSTPRFDTI
NRVVNALGLKLTVQHT

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5K1MH32

Antitoxin

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Source
ID
Structure
No matching records found

References