Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 85967..86555 Replicon plasmid plas1_Ab_8_4
Accession NZ_CP121366
Organism Acinetobacter baumannii strain Ab_8_4

Toxin (Protein)


Gene name relE Uniprot ID A0A5K1MH32
Locus tag P9J59_RS18675 Protein ID WP_000569859.1
Coordinates 85967..86263 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag P9J59_RS18680 Protein ID WP_000241337.1
Coordinates 86265..86555 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9J59_RS18660 (P9J59_18660) 81941..83233 + 1293 WP_024436605.1 MFS transporter -
P9J59_RS18665 (P9J59_18665) 83246..84151 + 906 WP_005130397.1 aromatic amino acid DMT transporter YddG -
P9J59_RS18670 (P9J59_18670) 84296..85630 + 1335 WP_032050497.1 ISNCY family transposase -
P9J59_RS18675 (P9J59_18675) 85967..86263 + 297 WP_000569859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9J59_RS18680 (P9J59_18680) 86265..86555 + 291 WP_000241337.1 putative addiction module antidote protein Antitoxin
P9J59_RS18685 (P9J59_18685) 86917..88082 + 1166 WP_085942227.1 IS3-like element ISAba22 family transposase -
P9J59_RS18690 (P9J59_18690) 88216..89439 + 1224 WP_123794025.1 IS256 family transposase -
P9J59_RS18695 (P9J59_18695) 89503..89787 - 285 WP_000156168.1 putative quinol monooxygenase -
P9J59_RS18700 (P9J59_18700) 89808..90806 - 999 WP_004740250.1 zinc-binding alcohol dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..101824 101824
- inside IScluster/Tn - - 84308..89439 5131


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11554.35 Da        Isoelectric Point: 8.5037

>T276327 WP_000569859.1 NZ_CP121366:85967-86263 [Acinetobacter baumannii]
MIEIKRLPEFDEWLDGLKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGAGWRMYYIQHGDVVIVMLGGGEKS
TQKDDIKKAVKLSKTLED

Download         Length: 297 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10584.24 Da        Isoelectric Point: 5.1133

>AT276327 WP_000241337.1 NZ_CP121366:86265-86555 [Acinetobacter baumannii]
MVKVADLPSFDMAESLKTEEDIVMYLNMVLEENDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRQDSTPRFDTI
NRVVNALGLKLTVQHT

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5K1MH32

Antitoxin

Source ID Structure

References