276315

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 42358..42959 Replicon plasmid pVP441
Accession NZ_CP121358
Organism Escherichia coli strain rl0044

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag P9060_RS27145 Protein ID WP_001216034.1
Coordinates 42579..42959 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag P9060_RS27140 Protein ID WP_001190712.1
Coordinates 42358..42579 (+) Length 74 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9060_RS27085 (P9060_27085) 37544..37783 + 240 WP_000476201.1 hypothetical protein -
P9060_RS27090 (P9060_27090) 37780..38505 + 726 WP_112987928.1 ead/Ea22-like family protein -
P9060_RS27095 (P9060_27095) 38507..38701 + 195 WP_000224731.1 hypothetical protein -
P9060_RS27100 (P9060_27100) 38703..38881 + 179 Protein_59 hypothetical protein -
P9060_RS27105 (P9060_27105) 39215..39787 + 573 WP_097416341.1 DUF551 domain-containing protein -
P9060_RS27110 (P9060_27110) 39780..40061 + 282 WP_000002100.1 ASCH domain-containing protein -
P9060_RS27115 (P9060_27115) 40085..40378 + 294 WP_000267996.1 hypothetical protein -
P9060_RS27120 (P9060_27120) 40403..40612 + 210 WP_085438024.1 hypothetical protein -
P9060_RS27125 (P9060_27125) 40609..41358 + 750 WP_085438025.1 hypothetical protein -
P9060_RS27130 (P9060_27130) 41342..41626 + 285 WP_096970304.1 antitoxin PHD -
P9060_RS27135 (P9060_27135) 41896..42285 + 390 WP_000506727.1 S24 family peptidase -
P9060_RS27140 (P9060_27140) 42358..42579 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P9060_RS27145 (P9060_27145) 42579..42959 + 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
P9060_RS27150 (P9060_27150) 42964..43161 + 198 WP_000113017.1 hypothetical protein -
P9060_RS27155 (P9060_27155) 43194..43970 - 777 WP_054192288.1 hypothetical protein -
P9060_RS27160 (P9060_27160) 43977..44627 - 651 WP_001108662.1 DUF2829 domain-containing protein -
P9060_RS27165 (P9060_27165) 44642..45136 - 495 WP_054192289.1 dUTP diphosphatase -
P9060_RS27170 (P9060_27170) 45133..45609 - 477 WP_096970305.1 hypothetical protein -
P9060_RS27175 (P9060_27175) 45606..45950 - 345 WP_202603232.1 hypothetical protein -
P9060_RS27180 (P9060_27180) 46024..47052 - 1029 WP_054192291.1 tyrosine-type recombinase/integrase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94075 94075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T276315 WP_001216034.1 NZ_CP121358:42579-42959 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp


Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT276315 WP_001190712.1 NZ_CP121358:42358-42579 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0AJ64


Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References