Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4017197..4017815 Replicon chromosome
Accession NZ_CP121356
Organism Escherichia coli strain rl0044

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P9060_RS20365 Protein ID WP_001291435.1
Coordinates 4017597..4017815 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P9060_RS20360 Protein ID WP_000344800.1
Coordinates 4017197..4017571 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9060_RS20350 (4012286) 4012286..4013479 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P9060_RS20355 (4013502) 4013502..4016651 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P9060_RS20360 (4017197) 4017197..4017571 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P9060_RS20365 (4017597) 4017597..4017815 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P9060_RS20370 (4017987) 4017987..4018538 + 552 WP_000102564.1 maltose O-acetyltransferase -
P9060_RS20375 (4018654) 4018654..4019124 + 471 WP_000136192.1 YlaC family protein -
P9060_RS20380 (4019288) 4019288..4020838 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P9060_RS20385 (4020880) 4020880..4021233 - 354 WP_000878140.1 DUF1428 domain-containing protein -
P9060_RS20395 (4021612) 4021612..4021923 + 312 WP_000409911.1 MGMT family protein -
P9060_RS20400 (4021954) 4021954..4022526 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T276309 WP_001291435.1 NZ_CP121356:4017597-4017815 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT276309 WP_000344800.1 NZ_CP121356:4017197-4017571 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References