Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3161783..3162254 Replicon chromosome
Accession NZ_CP121356
Organism Escherichia coli strain rl0044

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag P9060_RS16045 Protein ID WP_001303511.1
Coordinates 3161976..3162254 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag P9060_RS16040 Protein ID WP_001302048.1
Coordinates 3161783..3161974 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9060_RS15985 (3156997) 3156997..3157152 - 156 WP_168997827.1 type I toxin-antitoxin system toxin HokD -
P9060_RS15990 (3157406) 3157406..3157663 - 258 WP_001176099.1 hypothetical protein -
P9060_RS15995 (3157804) 3157804..3158319 - 516 WP_001289996.1 hypothetical protein -
P9060_RS16000 (3158316) 3158316..3158492 - 177 WP_000753061.1 hypothetical protein -
P9060_RS16005 (3158485) 3158485..3158667 - 183 WP_001224945.1 hypothetical protein -
P9060_RS16010 (3158763) 3158763..3158963 - 201 WP_001546006.1 hypothetical protein -
P9060_RS16015 (3158960) 3158960..3159386 - 427 Protein_3139 DUF977 family protein -
P9060_RS16020 (3159427) 3159427..3160497 - 1071 WP_032166946.1 phage replisome organizer -
P9060_RS16025 (3160569) 3160569..3160994 - 426 WP_000693883.1 toxin YdaT family protein -
P9060_RS16030 (3160991) 3160991..3161293 - 303 WP_000172735.1 transcriptional regulator -
P9060_RS16035 (3161391) 3161391..3161762 + 372 WP_122986906.1 hypothetical protein -
P9060_RS16040 (3161783) 3161783..3161974 + 192 WP_001302048.1 hypothetical protein Antitoxin
P9060_RS16045 (3161976) 3161976..3162254 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9060_RS16050 (3162546) 3162546..3162701 + 156 WP_000379575.1 DUF1391 family protein -
P9060_RS16055 (3162703) 3162703..3162831 + 129 WP_000344974.1 protein YdfB -
P9060_RS16060 (3162861) 3162861..3163079 + 219 WP_001171942.1 protein YdfC -
P9060_RS16065 (3163102) 3163102..3163509 + 408 WP_032166907.1 hypothetical protein -
P9060_RS16070 (3163487) 3163487..3163720 - 234 WP_278242730.1 hypothetical protein -
P9060_RS16075 (3164281) 3164281..3164469 + 189 WP_000449192.1 cell division inhibition protein DicB -
P9060_RS16080 (3164466) 3164466..3164657 + 192 WP_032166926.1 DUF1482 family protein -
P9060_RS16085 (3164750) 3164750..3167221 + 2472 Protein_3153 3'-5' exoribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3124097..3176699 52602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T276307 WP_001303511.1 NZ_CP121356:3161976-3162254 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT276307 WP_001302048.1 NZ_CP121356:3161783-3161974 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References