Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 5535855..5536474 Replicon chromosome
Accession NZ_CP121355
Organism Mesorhizobium sp. WSM4906

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QAZ22_RS26925 Protein ID WP_278203796.1
Coordinates 5536220..5536474 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QAZ22_RS26920 Protein ID WP_278203795.1
Coordinates 5535855..5536223 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAZ22_RS26895 (QAZ22_26895) 5531621..5532988 - 1368 WP_278203789.1 IS66 family transposase -
QAZ22_RS26900 (QAZ22_26900) 5533020..5533358 - 339 WP_278203791.1 hypothetical protein -
QAZ22_RS26905 (QAZ22_26905) 5533513..5533794 + 282 WP_278203792.1 acylphosphatase -
QAZ22_RS26910 (QAZ22_26910) 5533997..5534644 + 648 WP_278203793.1 TetR/AcrR family transcriptional regulator -
QAZ22_RS26915 (QAZ22_26915) 5534695..5535858 + 1164 WP_278203794.1 isovaleryl-CoA dehydrogenase -
QAZ22_RS26920 (QAZ22_26920) 5535855..5536223 - 369 WP_278203795.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QAZ22_RS26925 (QAZ22_26925) 5536220..5536474 - 255 WP_278203796.1 type II toxin-antitoxin system HicA family toxin Toxin
QAZ22_RS26930 (QAZ22_26930) 5536580..5538187 + 1608 WP_278203797.1 carboxyl transferase domain-containing protein -
QAZ22_RS26935 (QAZ22_26935) 5538190..5538720 + 531 WP_278203799.1 O-acetyl-ADP-ribose deacetylase -
QAZ22_RS26940 (QAZ22_26940) 5539024..5540988 + 1965 WP_278203801.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-77)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9394.87 Da        Isoelectric Point: 11.4362

>T276291 WP_278203796.1 NZ_CP121355:c5536474-5536220 [Mesorhizobium sp. WSM4906]
MKAAHRQTLDKIFANPVSTSIKWRDAEALLVALGARVSEGRGSRVRFTLNGITLRVHRPHPSPDTKAYVVREIRTFLIDS
GVEL

Download         Length: 255 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13794.42 Da        Isoelectric Point: 5.2645

>AT276291 WP_278203795.1 NZ_CP121355:c5536223-5535855 [Mesorhizobium sp. WSM4906]
MKPYKGYLGTIEFDENDVVFHGRIIGIRDIFTYEADSAEELLKAFHECVDDYLEFCAEQNKEPEKPFSGKLALRTTPEVH
RLVSRAASSDGKSINQWVSDTLAEAARKRIDEGSTKVTSRAH

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References