276272

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2043545..2044074 Replicon chromosome
Accession NZ_CP121344
Organism Corynebacterium glutamicum strain Cg21420

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag P9K31_RS09360 Protein ID WP_075348157.1
Coordinates 2043545..2043844 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1B4WJV4
Locus tag P9K31_RS09365 Protein ID WP_060564305.1
Coordinates 2043841..2044074 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9K31_RS09325 (P9K31_09325) 2038888..2039466 + 579 WP_060564312.1 ATP-binding cassette domain-containing protein -
P9K31_RS09330 (P9K31_09330) 2039471..2040496 + 1026 WP_060564311.1 hypothetical protein -
P9K31_RS09335 (P9K31_09335) 2040646..2041029 - 384 WP_060564310.1 class I SAM-dependent methyltransferase -
P9K31_RS09340 (P9K31_09340) 2041193..2041651 - 459 WP_060564309.1 NUDIX domain-containing protein -
P9K31_RS09345 (P9K31_09345) 2041871..2042383 + 513 WP_146144404.1 hypothetical protein -
P9K31_RS09350 (P9K31_09350) 2042465..2043022 + 558 WP_060564307.1 DUF6434 domain-containing protein -
P9K31_RS09355 (P9K31_09355) 2043240..2043608 - 369 WP_060564306.1 helix-turn-helix domain-containing protein -
P9K31_RS09360 (P9K31_09360) 2043545..2043844 - 300 WP_075348157.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P9K31_RS09365 (P9K31_09365) 2043841..2044074 - 234 WP_060564305.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
P9K31_RS09370 (P9K31_09370) 2044341..2044781 - 441 WP_038583357.1 YtoQ family protein -
P9K31_RS09375 (P9K31_09375) 2045115..2045360 - 246 WP_060564304.1 hypothetical protein -
P9K31_RS09380 (P9K31_09380) 2045525..2046610 - 1086 WP_004568081.1 redox-regulated ATPase YchF -
P9K31_RS09385 (P9K31_09385) 2046806..2048029 + 1224 WP_004568082.1 alpha/beta hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-74)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11529.07 Da        Isoelectric Point: 10.6281

>T276272 WP_075348157.1 NZ_CP121344:c2043844-2043545 [Corynebacterium glutamicum]
VSRYLLTPAAQHDLSLIWDFTESRWGISQAKKYIREIQSAVEYVAQDANRGRSREEIRLGYKSTAVGSHVIFYVQRTSHW
KAMKQPVWRPTSARQFVTS

Download         Length: 300 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8475.39 Da        Isoelectric Point: 4.1948

>AT276272 WP_060564305.1 NZ_CP121344:c2044074-2043841 [Corynebacterium glutamicum]
MAMNTSISLDDHFASFLSEQVESGRYQTASEVIRAGLRLLEEREARLTALRAALVNGEMSGEAEEFDFDAFIASKSS

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4WJV4

References