Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 913181..913722 Replicon plasmid unnamedB
Accession NZ_CP121310
Organism Ensifer adhaerens strain Casida A-T305

Toxin (Protein)


Gene name parE Uniprot ID A0A1H0CJK8
Locus tag P4B07_RS32215 Protein ID WP_034798189.1
Coordinates 913429..913722 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1H0CJP6
Locus tag P4B07_RS32210 Protein ID WP_034798187.1
Coordinates 913181..913429 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B07_RS32200 (P4B07_32200) 908709..911402 + 2694 WP_034798183.1 TonB-dependent receptor -
P4B07_RS32205 (P4B07_32205) 911453..912910 - 1458 WP_234798828.1 MDR family MFS transporter -
P4B07_RS32210 (P4B07_32210) 913181..913429 + 249 WP_034798187.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
P4B07_RS32215 (P4B07_32215) 913429..913722 + 294 WP_034798189.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P4B07_RS32220 (P4B07_32220) 913794..915233 - 1440 WP_034805416.1 NAD-dependent succinate-semialdehyde dehydrogenase -
P4B07_RS32225 (P4B07_32225) 915460..916449 - 990 WP_051659649.1 LysR family transcriptional regulator -
P4B07_RS32230 (P4B07_32230) 916744..917259 + 516 WP_051659650.1 SgcJ/EcaC family oxidoreductase -
P4B07_RS32235 (P4B07_32235) 917252..917725 + 474 WP_034803391.1 SRPBCC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..1459375 1459375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10969.62 Da        Isoelectric Point: 6.9895

>T276270 WP_034798189.1 NZ_CP121310:913429-913722 [Ensifer adhaerens]
MAFRLSVAAEEDIIAIAADGVRLFGSAQARRYHDELFAVFALIAANPRMARERTELSPPMRIHPFKAHLVVYRVEADGDI
LVVRVRHGHEDWISNAF

Download         Length: 294 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9247.39 Da        Isoelectric Point: 8.5610

>AT276270 WP_034798187.1 NZ_CP121310:913181-913429 [Ensifer adhaerens]
MATMNVSLPDPMKDWVEAQTRTGRYANASDYVRDLIRRDQERNDKVAVMQRFVDDGLKSGVGSRSKDELFSAALTRAEVP
RG

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H0CJK8

Antitoxin

Source ID Structure
AlphaFold DB A0A1H0CJP6

References