Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 349947..350617 Replicon plasmid unnamedB
Accession NZ_CP121310
Organism Ensifer adhaerens strain Casida A-T305

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P4B07_RS29695 Protein ID WP_034798590.1
Coordinates 350198..350617 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P4B07_RS29690 Protein ID WP_034798588.1
Coordinates 349947..350201 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B07_RS29655 (P4B07_29655) 344980..345663 - 684 WP_082584643.1 hypothetical protein -
P4B07_RS29660 (P4B07_29660) 345810..346037 + 228 WP_082936641.1 helix-turn-helix domain-containing protein -
P4B07_RS29665 (P4B07_29665) 346491..346899 + 409 Protein_359 hypothetical protein -
P4B07_RS29670 (P4B07_29670) 346887..347138 - 252 WP_063979521.1 hypothetical protein -
P4B07_RS29675 (P4B07_29675) 348068..349055 + 988 Protein_361 HWE histidine kinase domain-containing protein -
P4B07_RS29680 (P4B07_29680) 349079..349432 + 354 WP_034798587.1 response regulator -
P4B07_RS29685 (P4B07_29685) 349591..349770 + 180 Protein_363 DNA ligase -
P4B07_RS29690 (P4B07_29690) 349947..350201 + 255 WP_034798588.1 plasmid stabilization protein Antitoxin
P4B07_RS29695 (P4B07_29695) 350198..350617 + 420 WP_034798590.1 type II toxin-antitoxin system VapC family toxin Toxin
P4B07_RS29700 (P4B07_29700) 351270..352097 + 828 WP_034798593.1 transporter substrate-binding domain-containing protein -
P4B07_RS29705 (P4B07_29705) 352157..353437 + 1281 WP_082936642.1 FAD-binding oxidoreductase -
P4B07_RS29710 (P4B07_29710) 353467..354438 + 972 WP_051659453.1 amino acid ABC transporter permease -
P4B07_RS29715 (P4B07_29715) 354446..355318 + 873 WP_234798872.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..1459375 1459375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14897.00 Da        Isoelectric Point: 4.6556

>T276269 WP_034798590.1 NZ_CP121310:350198-350617 [Ensifer adhaerens]
MIVLDTNVVSEAMKPAPDLAVRNWLNDQVAETLFLSSVTLAELLFGIAALPEGRRKKALADTLDGLLELFDDRVLSFDTA
AARHYADLTATPRAVGKGFQTPDGYIAAIAASKGFTIATRDTSPFEAAGVPVVNPWNHL

Download         Length: 420 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9553.82 Da        Isoelectric Point: 5.1786

>AT276269 WP_034798588.1 NZ_CP121310:349947-350201 [Ensifer adhaerens]
MAILTVRNVPDEVHRALRVRAANHGRSTEAEVREILERAVKPEQRIRIGDALAELSGRLGLTNDDFEVFDQMQDKAPAEP
MRFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References