Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1086151..1086851 Replicon plasmid unnamedA
Accession NZ_CP121309
Organism Ensifer adhaerens strain Casida A-T305

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P4B07_RS24915 Protein ID WP_034800191.1
Coordinates 1086414..1086851 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1H0BN26
Locus tag P4B07_RS24910 Protein ID WP_034800189.1
Coordinates 1086151..1086417 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4B07_RS24890 (P4B07_24890) 1082490..1083539 + 1050 WP_034800187.1 ABC transporter permease -
P4B07_RS24895 (P4B07_24895) 1083541..1084482 + 942 WP_034800188.1 ABC transporter permease -
P4B07_RS24900 (P4B07_24900) 1084479..1085770 + 1292 Protein_979 amidohydrolase family protein -
P4B07_RS24905 (P4B07_24905) 1085818..1085972 - 155 Protein_980 transcriptional regulator -
P4B07_RS24910 (P4B07_24910) 1086151..1086417 + 267 WP_034800189.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
P4B07_RS24915 (P4B07_24915) 1086414..1086851 + 438 WP_034800191.1 type II toxin-antitoxin system VapC family toxin Toxin
P4B07_RS24920 (P4B07_24920) 1087128..1087376 + 249 WP_034800193.1 hypothetical protein -
P4B07_RS24925 (P4B07_24925) 1087593..1088633 + 1041 WP_034800195.1 ABC transporter substrate-binding protein -
P4B07_RS24930 (P4B07_24930) 1088759..1089523 + 765 WP_060529703.1 ABC transporter permease -
P4B07_RS24935 (P4B07_24935) 1089539..1090342 + 804 WP_034800199.1 ABC transporter permease -
P4B07_RS24940 (P4B07_24940) 1090339..1091427 + 1089 WP_034800202.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - katA 1..1736931 1736931


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

SpoVT-AbrB domain

(17-54)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15304.68 Da        Isoelectric Point: 6.9280

>T276266 WP_034800191.1 NZ_CP121309:1086414-1086851 [Ensifer adhaerens]
VSNLFMLDTNIVSELARNPRGQVAERIAAVGSEAICVSIITAAELRYGCAKKGSPKLLAQIEALLESILVLALDVPADAK
YGNIRTELEAAGKPIGPNDLLIAAHACAAGAVLVTANAREFTRIPNLRVENWLDATSKQLRGASN

Download         Length: 438 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.58 Da        Isoelectric Point: 4.8781

>AT276266 WP_034800189.1 NZ_CP121309:1086151-1086417 [Ensifer adhaerens]
MPQIRHNEPPAREAKLFRNNKSQAVRIPADFELPGDRVMIHRDGDRLIIEPLRRKNLLEVLAGLDPLGPEDQFPDIDETL
LPAKEIDL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1H0BN26

References