Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4484569..4485085 Replicon chromosome
Accession NZ_CP121298
Organism Salmonella enterica subsp. enterica strain KKP 3080

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag P1839_RS21735 Protein ID WP_000220578.1
Coordinates 4484569..4484853 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag P1839_RS21740 Protein ID WP_000212724.1
Coordinates 4484843..4485085 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1839_RS21720 (4479781) 4479781..4481433 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
P1839_RS21725 (4481842) 4481842..4483980 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P1839_RS21730 (4484101) 4484101..4484565 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P1839_RS21735 (4484569) 4484569..4484853 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1839_RS21740 (4484843) 4484843..4485085 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P1839_RS21745 (4485163) 4485163..4487076 - 1914 WP_001212137.1 BglG family transcription antiterminator -
P1839_RS21750 (4487093) 4487093..4487833 - 741 WP_000779263.1 KDGP aldolase family protein -
P1839_RS21755 (4487830) 4487830..4488948 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P1839_RS21760 (4488932) 4488932..4490065 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T276264 WP_000220578.1 NZ_CP121298:c4484853-4484569 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT276264 WP_000212724.1 NZ_CP121298:c4485085-4484843 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References