Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3751704..3752324 Replicon chromosome
Accession NZ_CP121298
Organism Salmonella enterica subsp. enterica strain KKP 3080

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1839_RS18275 Protein ID WP_001280991.1
Coordinates 3752106..3752324 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1839_RS18270 Protein ID WP_000344807.1
Coordinates 3751704..3752078 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1839_RS18260 (3746843) 3746843..3748036 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1839_RS18265 (3748059) 3748059..3751208 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1839_RS18270 (3751704) 3751704..3752078 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1839_RS18275 (3752106) 3752106..3752324 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P1839_RS18280 (3752503) 3752503..3753054 + 552 WP_001278792.1 maltose O-acetyltransferase -
P1839_RS18285 (3753171) 3753171..3753641 + 471 WP_000136181.1 YlaC family protein -
P1839_RS18290 (3753697) 3753697..3753837 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1839_RS18295 (3753843) 3753843..3754103 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
P1839_RS18300 (3754328) 3754328..3755878 + 1551 WP_000213139.1 EAL domain-containing protein -
P1839_RS18310 (3756109) 3756109..3756498 + 390 WP_000961285.1 MGMT family protein -
P1839_RS18315 (3756531) 3756531..3757100 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T276262 WP_001280991.1 NZ_CP121298:3752106-3752324 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT276262 WP_000344807.1 NZ_CP121298:3751704-3752078 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References