276252

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 559246..560006 Replicon chromosome
Accession NZ_CP121298
Organism Salmonella enterica subsp. enterica strain KKP 3080

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag P1839_RS02675 Protein ID WP_000533909.1
Coordinates 559521..560006 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag P1839_RS02670 Protein ID WP_000965886.1
Coordinates 559246..559533 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1839_RS02645 (554541) 554541..554843 + 303 WP_000605590.1 YsaB family lipoprotein -
P1839_RS02650 (554982) 554982..555893 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
P1839_RS02655 (555903) 555903..557972 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
P1839_RS02660 (558154) 558154..558429 + 276 Protein_502 IS3 family transposase -
P1839_RS02665 (558601) 558601..559068 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
P1839_RS02670 (559246) 559246..559533 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
P1839_RS02675 (559521) 559521..560006 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
P1839_RS02680 (560378) 560378..560917 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
P1839_RS02685 (561091) 561091..561303 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
P1839_RS02690 (561592) 561592..561882 - 291 WP_000455790.1 HTH-type transcriptional regulator -
P1839_RS02695 (562321) 562321..563032 + 712 Protein_509 DUF3053 domain-containing protein -
P1839_RS02700 (563082) 563082..564056 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
P1839_RS02705 (564275) 564275..564937 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T276252 WP_000533909.1 NZ_CP121298:559521-560006 [Salmonella enterica subsp. enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT276252 WP_000965886.1 NZ_CP121298:559246-559533 [Salmonella enterica subsp. enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References