Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3474859..3475673 Replicon chromosome
Accession NZ_CP121297
Organism Salmonella enterica subsp. enterica strain KKP 1762

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag P1N06_RS16975 Protein ID WP_000971655.1
Coordinates 3475146..3475673 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P1N06_RS16970 Protein ID WP_000855694.1
Coordinates 3474859..3475149 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1N06_RS16940 (3470788) 3470788..3471438 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
P1N06_RS16945 (3471894) 3471894..3472337 + 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P1N06_RS16950 (3472769) 3472769..3473218 + 450 WP_000381613.1 hypothetical protein -
P1N06_RS16955 (3473203) 3473203..3473550 + 348 WP_001555786.1 DUF1493 family protein -
P1N06_RS16960 (3473823) 3473823..3474149 - 327 WP_076737359.1 hypothetical protein -
P1N06_RS16965 (3474390) 3474390..3474590 + 201 Protein_3296 IS3 family transposase -
P1N06_RS16970 (3474859) 3474859..3475149 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P1N06_RS16975 (3475146) 3475146..3475673 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
P1N06_RS16980 (3475746) 3475746..3476169 - 424 Protein_3299 transposase -
P1N06_RS16985 (3476396) 3476396..3477052 + 657 WP_000420459.1 protein-serine/threonine phosphatase -
P1N06_RS16990 (3477223) 3477223..3477743 - 521 Protein_3301 cytoplasmic protein -
P1N06_RS16995 (3477902) 3477902..3480469 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3475746..3475940 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T276247 WP_000971655.1 NZ_CP121297:3475146-3475673 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT276247 WP_000855694.1 NZ_CP121297:3474859-3475149 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References