Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 3175606..3176132 | Replicon | chromosome |
Accession | NC_017660 | ||
Organism | Escherichia coli KO11FL |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1EXL1 |
Locus tag | KO11_RS15710 | Protein ID | WP_000323025.1 |
Coordinates | 3175845..3176132 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | S1F6D3 |
Locus tag | KO11_RS15705 | Protein ID | WP_000534858.1 |
Coordinates | 3175606..3175845 (+) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KO11_RS15680 | 3170968..3171324 | + | 357 | WP_001310834.1 | class I SAM-dependent methyltransferase | - |
KO11_RS28205 | 3171935..3172222 | + | 288 | Protein_2970 | hypothetical protein | - |
KO11_RS15695 | 3172991..3174304 | + | 1314 | WP_000589005.1 | ISNCY family transposase | - |
KO11_RS15700 | 3174741..3175073 | - | 333 | WP_001301033.1 | protein FlxA | - |
KO11_RS25995 | 3175276..3175581 | - | 306 | WP_001326990.1 | hypothetical protein | - |
KO11_RS15705 | 3175606..3175845 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
KO11_RS15710 | 3175845..3176132 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
KO11_RS15715 | 3176204..3176359 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
KO11_RS15720 | 3176576..3176827 | + | 252 | WP_000980994.1 | hypothetical protein | - |
KO11_RS15725 | 3176894..3177172 | + | 279 | WP_012304870.1 | hypothetical protein | - |
KO11_RS15730 | 3177174..3178223 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
KO11_RS15735 | 3178237..3178989 | + | 753 | WP_001047135.1 | antitermination protein | - |
KO11_RS27805 | 3179267..3179356 | - | 90 | WP_120795389.1 | hypothetical protein | - |
KO11_RS15740 | 3179411..3179623 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
KO11_RS15745 | 3179924..3180139 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 3155983..3211440 | 55457 | |
- | flank | IS/Tn | - | - | 3180555..3181763 | 1208 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T27624 WP_000323025.1 NC_017660:3175845-3176132 [Escherichia coli KO11FL]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T27624 NC_017660:3175845-3176132 [Escherichia coli KO11FL]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT27624 WP_000534858.1 NC_017660:3175606-3175845 [Escherichia coli KO11FL]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT27624 NC_017660:3175606-3175845 [Escherichia coli KO11FL]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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