27624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3175606..3176132 Replicon chromosome
Accession NC_017660
Organism Escherichia coli KO11FL

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KO11_RS15710 Protein ID WP_000323025.1
Coordinates 3175845..3176132 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KO11_RS15705 Protein ID WP_000534858.1
Coordinates 3175606..3175845 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KO11_RS15680 3170968..3171324 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
KO11_RS28205 3171935..3172222 + 288 Protein_2970 hypothetical protein -
KO11_RS15695 3172991..3174304 + 1314 WP_000589005.1 ISNCY family transposase -
KO11_RS15700 3174741..3175073 - 333 WP_001301033.1 protein FlxA -
KO11_RS25995 3175276..3175581 - 306 WP_001326990.1 hypothetical protein -
KO11_RS15705 3175606..3175845 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KO11_RS15710 3175845..3176132 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KO11_RS15715 3176204..3176359 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KO11_RS15720 3176576..3176827 + 252 WP_000980994.1 hypothetical protein -
KO11_RS15725 3176894..3177172 + 279 WP_012304870.1 hypothetical protein -
KO11_RS15730 3177174..3178223 + 1050 WP_001265199.1 DUF968 domain-containing protein -
KO11_RS15735 3178237..3178989 + 753 WP_001047135.1 antitermination protein -
KO11_RS27805 3179267..3179356 - 90 WP_120795389.1 hypothetical protein -
KO11_RS15740 3179411..3179623 - 213 WP_000087756.1 cold shock-like protein CspF -
KO11_RS15745 3179924..3180139 + 216 WP_000066484.1 cold shock-like protein CspB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3155983..3211440 55457
- flank IS/Tn - - 3180555..3181763 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T27624 WP_000323025.1 NC_017660:3175845-3176132 [Escherichia coli KO11FL]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T27624 NC_017660:3175845-3176132 [Escherichia coli KO11FL]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT27624 WP_000534858.1 NC_017660:3175606-3175845 [Escherichia coli KO11FL]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT27624 NC_017660:3175606-3175845 [Escherichia coli KO11FL]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References