Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 334629..335410 Replicon chromosome
Accession NZ_CP121297
Organism Salmonella enterica subsp. enterica strain KKP 1762

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A744N2R8
Locus tag P1N06_RS01450 Protein ID WP_061383248.1
Coordinates 334919..335410 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag P1N06_RS01445 Protein ID WP_001110452.1
Coordinates 334629..334922 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1N06_RS01420 (330953) 330953..331858 + 906 WP_064042929.1 YjiK family protein -
P1N06_RS01425 (332153) 332153..332527 - 375 WP_232234247.1 Ig-like domain-containing protein -
P1N06_RS01430 (332667) 332667..332954 - 288 WP_001269916.1 transcriptional regulator RtsB -
P1N06_RS01435 (332951) 332951..333826 - 876 WP_278208502.1 AraC family transcriptional regulator -
P1N06_RS01440 (334090) 334090..334312 - 223 Protein_269 hypothetical protein -
P1N06_RS01445 (334629) 334629..334922 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
P1N06_RS01450 (334919) 334919..335410 + 492 WP_061383248.1 GNAT family N-acetyltransferase Toxin
P1N06_RS01455 (335709) 335709..336461 - 753 WP_064042932.1 non-specific acid phosphatase -
P1N06_RS01460 (336561) 336561..336637 - 77 Protein_273 porin family protein -
P1N06_RS01465 (337017) 337017..337091 + 75 Protein_274 helix-turn-helix domain-containing protein -
P1N06_RS01475 (337363) 337363..337938 - 576 WP_001188509.1 transcriptional regulator -
P1N06_RS01480 (337975) 337975..339678 - 1704 WP_076737628.1 protein-disulfide reductase DsbD -
P1N06_RS01485 (339654) 339654..340001 - 348 WP_076737629.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17649.45 Da        Isoelectric Point: 7.7297

>T276239 WP_061383248.1 NZ_CP121297:334919-335410 [Salmonella enterica subsp. enterica]
MISTPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT276239 WP_001110452.1 NZ_CP121297:334629-334922 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A744N2R8

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References