Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2508315..2509129 Replicon chromosome
Accession NZ_CP121296
Organism Salmonella enterica subsp. enterica strain KKP 1213

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag P1838_RS11980 Protein ID WP_000971655.1
Coordinates 2508315..2508842 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P1838_RS11985 Protein ID WP_000855694.1
Coordinates 2508839..2509129 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1838_RS11960 (2503519) 2503519..2506086 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
P1838_RS11965 (2506245) 2506245..2506765 + 521 Protein_2314 cytoplasmic protein -
P1838_RS11970 (2506936) 2506936..2507592 - 657 WP_000420459.1 protein-serine/threonine phosphatase -
P1838_RS11975 (2507819) 2507819..2508242 + 424 Protein_2316 transposase -
P1838_RS11980 (2508315) 2508315..2508842 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
P1838_RS11985 (2508839) 2508839..2509129 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P1838_RS11990 (2509398) 2509398..2509598 - 201 Protein_2319 IS3 family transposase -
P1838_RS11995 (2509839) 2509839..2510165 + 327 WP_076737359.1 hypothetical protein -
P1838_RS12000 (2510438) 2510438..2510785 - 348 WP_001555786.1 DUF1493 family protein -
P1838_RS12005 (2510770) 2510770..2511219 - 450 WP_000381613.1 hypothetical protein -
P1838_RS12010 (2511651) 2511651..2512094 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P1838_RS12015 (2512550) 2512550..2513200 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2508048..2508242 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T276232 WP_000971655.1 NZ_CP121296:c2508842-2508315 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT276232 WP_000855694.1 NZ_CP121296:c2509129-2508839 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References