Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2360967..2361627 Replicon chromosome
Accession NZ_CP121296
Organism Salmonella enterica subsp. enterica strain KKP 1213

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag P1838_RS11305 Protein ID WP_000244756.1
Coordinates 2361214..2361627 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag P1838_RS11300 Protein ID WP_000351186.1
Coordinates 2360967..2361233 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1838_RS11280 (2356896) 2356896..2358329 - 1434 WP_053444816.1 6-phospho-beta-glucosidase BglA -
P1838_RS11285 (2358487) 2358487..2358798 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
P1838_RS11290 (2358962) 2358962..2359621 + 660 WP_053444817.1 hemolysin III family protein -
P1838_RS11295 (2359737) 2359737..2360717 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
P1838_RS11300 (2360967) 2360967..2361233 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
P1838_RS11305 (2361214) 2361214..2361627 + 414 WP_000244756.1 protein YgfX Toxin
P1838_RS11310 (2361680) 2361680..2362201 - 522 WP_001055885.1 flavodoxin FldB -
P1838_RS11315 (2362314) 2362314..2363210 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
P1838_RS11320 (2363234) 2363234..2363947 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P1838_RS11325 (2363953) 2363953..2365686 + 1734 WP_278208069.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T276231 WP_000244756.1 NZ_CP121296:2361214-2361627 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT276231 WP_000351186.1 NZ_CP121296:2360967-2361233 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References