Detailed information of TA system TA276230

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2290339..2292037
• Replicon: chromosome
• Accession: NZ_CP121296
• Organism: Salmonella enterica subsp. enterica strain KKP 1213

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: P1838_RS10925
• Protein ID: WP_076737406.1
• Coordinates: 2290339..2291268 (-)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: P1838_RS10930
• Protein ID: WP_176202033.1
• Coordinates: 2291255..2292037 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P1838_RS10915 (2285668)	2285668..2288955	+	3288	WP_076737408.1	ATP-binding protein	-
P1838_RS10920 (2288957)	2288957..2290114	+	1158	WP_076737407.1	DUF3322 domain-containing protein	-
P1838_RS10925 (2290339)	2290339..2291268	-	930	WP_076737406.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
P1838_RS10930 (2291255)	2291255..2292037	-	783	WP_176202033.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
P1838_RS10935 (2292186)	2292186..2293055	+	870	WP_076737405.1	hypothetical protein	-
P1838_RS10940 (2293096)	2293096..2293890	+	795	WP_076737404.1	hypothetical protein	-
P1838_RS10945 (2293973)	2293973..2294941	-	969	WP_232234240.1	DUF3644 domain-containing protein	-
P1838_RS10950 (2295066)	2295066..2295212	-	147	WP_232234239.1	hypothetical protein	-
P1838_RS10955 (2295785)	2295785..2296247	+	463	Protein_2117	hypothetical protein	-
P1838_RS10960 (2296250)	2296250..2296465	+	216	WP_076737724.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2267428..2296465	29037

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-261)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35094.43 Da
• Isoelectric Point: 6.3527

>T276230 WP_076737406.1 NZ_CP121296:c2291268-2290339 [Salmonella enterica subsp. enterica]
MDLRDSYARQVRLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKAYADRDTDLATINDALMRITESLNGR
PGITAIRQENKADEKRIIVNTADAQIKIEVSPVWRGLLLPATEMPVCEQVEMEYGFTTMNVVSQADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPIAELLAPNWDTSRIATLYAQEFSGMTQRETSLESLLSVTTLLPQTL
KSHLTDRDRQFLLSYKQITPDWSLYRYPEIQHLPAIRWKLRNLAVLKEKNPAKYAATVNKLEGVLEQYF

Nucleotide

• Length: 930 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29289.47 Da
• Isoelectric Point: 7.8227

>AT276230 WP_176202033.1 NZ_CP121296:c2292037-2291255 [Salmonella enterica subsp. enterica]
MPNYLNWLMQNTQPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSAMFVTLYTSGLTVDVTPFTTTLNIGDRQLTGSVPELAAYEIA
GGVPSLISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVMLYLARRNEHPYFRYLDQSDIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp