Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1070002..1070783 Replicon chromosome
Accession NZ_CP121296
Organism Salmonella enterica subsp. enterica strain KKP 1213

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A744N2R8
Locus tag P1838_RS05255 Protein ID WP_061383248.1
Coordinates 1070002..1070493 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag P1838_RS05260 Protein ID WP_001110452.1
Coordinates 1070490..1070783 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1838_RS05220 (1065411) 1065411..1065758 + 348 WP_076737629.1 divalent cation tolerance protein CutA -
P1838_RS05225 (1065734) 1065734..1067437 + 1704 WP_076737628.1 protein-disulfide reductase DsbD -
P1838_RS05230 (1067474) 1067474..1068049 + 576 WP_001188509.1 transcriptional regulator -
P1838_RS05240 (1068321) 1068321..1068395 - 75 Protein_1015 helix-turn-helix domain-containing protein -
P1838_RS05245 (1068775) 1068775..1068851 + 77 Protein_1016 porin family protein -
P1838_RS05250 (1068951) 1068951..1069703 + 753 WP_064042932.1 non-specific acid phosphatase -
P1838_RS05255 (1070002) 1070002..1070493 - 492 WP_061383248.1 GNAT family N-acetyltransferase Toxin
P1838_RS05260 (1070490) 1070490..1070783 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
P1838_RS05265 (1071100) 1071100..1071322 + 223 Protein_1020 hypothetical protein -
P1838_RS05270 (1071586) 1071586..1072461 + 876 WP_278208502.1 AraC family transcriptional regulator -
P1838_RS05275 (1072458) 1072458..1072745 + 288 WP_001269916.1 transcriptional regulator RtsB -
P1838_RS05280 (1072885) 1072885..1073259 + 375 WP_232234247.1 Ig-like domain-containing protein -
P1838_RS05285 (1073554) 1073554..1074459 - 906 WP_064042929.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17649.45 Da        Isoelectric Point: 7.7297

>T276227 WP_061383248.1 NZ_CP121296:c1070493-1070002 [Salmonella enterica subsp. enterica]
MISTPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT276227 WP_001110452.1 NZ_CP121296:c1070783-1070490 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A744N2R8

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References