Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 963221..963864 Replicon chromosome
Accession NZ_CP121296
Organism Salmonella enterica subsp. enterica strain KKP 1213

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag P1838_RS04690 Protein ID WP_000048134.1
Coordinates 963448..963864 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag P1838_RS04685 Protein ID WP_001261294.1
Coordinates 963221..963451 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1838_RS04675 (960235) 960235..962373 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P1838_RS04680 (962590) 962590..963054 + 465 WP_076737652.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P1838_RS04685 (963221) 963221..963451 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
P1838_RS04690 (963448) 963448..963864 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
P1838_RS04695 (963925) 963925..965838 - 1914 WP_149866235.1 BglG family transcription antiterminator -
P1838_RS04700 (965855) 965855..966595 - 741 WP_048591337.1 KDGP aldolase family protein -
P1838_RS04705 (966592) 966592..967710 - 1119 WP_076737650.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P1838_RS04710 (967694) 967694..968827 - 1134 WP_076737649.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T276226 WP_000048134.1 NZ_CP121296:963448-963864 [Salmonella enterica subsp. enterica]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT276226 WP_001261294.1 NZ_CP121296:963221-963451 [Salmonella enterica subsp. enterica]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References