Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 315607..316227 Replicon chromosome
Accession NZ_CP121296
Organism Salmonella enterica subsp. enterica strain KKP 1213

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1838_RS01675 Protein ID WP_001280991.1
Coordinates 316009..316227 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1838_RS01670 Protein ID WP_000344807.1
Coordinates 315607..315981 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1838_RS01660 (310746) 310746..311939 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1838_RS01665 (311962) 311962..315111 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1838_RS01670 (315607) 315607..315981 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1838_RS01675 (316009) 316009..316227 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P1838_RS01680 (316406) 316406..316957 + 552 WP_001278793.1 maltose O-acetyltransferase -
P1838_RS01685 (317073) 317073..317543 + 471 WP_080170962.1 YlaC family protein -
P1838_RS01690 (317599) 317599..317739 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1838_RS01695 (317745) 317745..318005 - 261 WP_000801421.1 type B 50S ribosomal protein L31 -
P1838_RS01700 (318230) 318230..319780 + 1551 WP_023210786.1 EAL domain-containing protein -
P1838_RS01710 (320011) 320011..320400 + 390 WP_278208425.1 MGMT family protein -
P1838_RS01715 (320433) 320433..321002 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T276224 WP_001280991.1 NZ_CP121296:316009-316227 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT276224 WP_000344807.1 NZ_CP121296:315607-315981 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References