Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4390294..4391075 Replicon chromosome
Accession NZ_CP121295
Organism Salmonella enterica subsp. enterica strain KKP 998

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A744N2R8
Locus tag P1837_RS21490 Protein ID WP_061383248.1
Coordinates 4390294..4390785 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag P1837_RS21495 Protein ID WP_001110452.1
Coordinates 4390782..4391075 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1837_RS21455 (4385703) 4385703..4386050 + 348 WP_076737629.1 divalent cation tolerance protein CutA -
P1837_RS21460 (4386026) 4386026..4387729 + 1704 WP_076737628.1 protein-disulfide reductase DsbD -
P1837_RS21465 (4387766) 4387766..4388341 + 576 WP_001188509.1 transcriptional regulator -
P1837_RS21475 (4388613) 4388613..4388687 - 75 Protein_4179 helix-turn-helix domain-containing protein -
P1837_RS21480 (4389067) 4389067..4389143 + 77 Protein_4180 porin family protein -
P1837_RS21485 (4389243) 4389243..4389995 + 753 WP_064042932.1 non-specific acid phosphatase -
P1837_RS21490 (4390294) 4390294..4390785 - 492 WP_061383248.1 GNAT family N-acetyltransferase Toxin
P1837_RS21495 (4390782) 4390782..4391075 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
P1837_RS21500 (4391392) 4391392..4391614 + 223 Protein_4184 hypothetical protein -
P1837_RS21505 (4391878) 4391878..4392753 + 876 WP_278208502.1 AraC family transcriptional regulator -
P1837_RS21510 (4392750) 4392750..4393037 + 288 WP_001269916.1 transcriptional regulator RtsB -
P1837_RS21515 (4393177) 4393177..4393551 + 375 WP_232234247.1 Ig-like domain-containing protein -
P1837_RS21520 (4393846) 4393846..4394751 - 906 WP_064042929.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17649.45 Da        Isoelectric Point: 7.7297

>T276223 WP_061383248.1 NZ_CP121295:c4390785-4390294 [Salmonella enterica subsp. enterica]
MISTPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT276223 WP_001110452.1 NZ_CP121295:c4391075-4390782 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A744N2R8

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References