Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4283515..4284158 Replicon chromosome
Accession NZ_CP121295
Organism Salmonella enterica subsp. enterica strain KKP 998

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag P1837_RS20925 Protein ID WP_000048134.1
Coordinates 4283742..4284158 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag P1837_RS20920 Protein ID WP_001261294.1
Coordinates 4283515..4283745 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1837_RS20910 (4280529) 4280529..4282667 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P1837_RS20915 (4282884) 4282884..4283348 + 465 WP_076737652.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P1837_RS20920 (4283515) 4283515..4283745 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
P1837_RS20925 (4283742) 4283742..4284158 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
P1837_RS20930 (4284219) 4284219..4286132 - 1914 WP_149866235.1 BglG family transcription antiterminator -
P1837_RS20935 (4286149) 4286149..4286889 - 741 WP_048591337.1 KDGP aldolase family protein -
P1837_RS20940 (4286886) 4286886..4288004 - 1119 WP_076737650.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P1837_RS20945 (4287988) 4287988..4289121 - 1134 WP_076737649.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T276222 WP_000048134.1 NZ_CP121295:4283742-4284158 [Salmonella enterica subsp. enterica]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT276222 WP_001261294.1 NZ_CP121295:4283515-4283745 [Salmonella enterica subsp. enterica]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References