Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4188590..4189166 Replicon chromosome
Accession NZ_CP121295
Organism Salmonella enterica subsp. enterica strain KKP 998

Toxin (Protein)


Gene name shpA Uniprot ID A0A4D6PC34
Locus tag P1837_RS20495 Protein ID WP_020839635.1
Coordinates 4188879..4189166 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag P1837_RS20490 Protein ID WP_000063143.1
Coordinates 4188590..4188892 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1837_RS20475 (4185100) 4185100..4187250 + 2151 WP_000379929.1 pyruvate/proton symporter BtsT -
P1837_RS20480 (4187345) 4187345..4187548 + 204 WP_000460616.1 YbdD/YjiX family protein -
P1837_RS20485 (4187559) 4187559..4188515 + 957 WP_000187838.1 GTPase -
P1837_RS20490 (4188590) 4188590..4188892 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
P1837_RS20495 (4188879) 4188879..4189166 - 288 WP_020839635.1 BrnT family toxin Toxin
P1837_RS20500 (4189419) 4189419..4190091 - 673 Protein_3989 winged helix-turn-helix domain-containing protein -
P1837_RS20505 (4190289) 4190289..4193798 + 3510 WP_076737682.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11241.75 Da        Isoelectric Point: 8.0998

>T276221 WP_020839635.1 NZ_CP121295:c4189166-4188879 [Salmonella enterica subsp. enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVICIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT276221 WP_000063143.1 NZ_CP121295:c4188892-4188590 [Salmonella enterica subsp. enterica]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6PC34

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References