Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3635913..3636533 Replicon chromosome
Accession NZ_CP121295
Organism Salmonella enterica subsp. enterica strain KKP 998

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P1837_RS17915 Protein ID WP_001280991.1
Coordinates 3636315..3636533 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P1837_RS17910 Protein ID WP_000344807.1
Coordinates 3635913..3636287 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1837_RS17900 (3631052) 3631052..3632245 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1837_RS17905 (3632268) 3632268..3635417 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
P1837_RS17910 (3635913) 3635913..3636287 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P1837_RS17915 (3636315) 3636315..3636533 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P1837_RS17920 (3636712) 3636712..3637263 + 552 WP_001278793.1 maltose O-acetyltransferase -
P1837_RS17925 (3637379) 3637379..3637849 + 471 WP_080170962.1 YlaC family protein -
P1837_RS17930 (3637905) 3637905..3638045 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P1837_RS17935 (3638051) 3638051..3638311 - 261 WP_000801421.1 type B 50S ribosomal protein L31 -
P1837_RS17940 (3638536) 3638536..3640086 + 1551 WP_023210786.1 EAL domain-containing protein -
P1837_RS17950 (3640317) 3640317..3640706 + 390 WP_278208425.1 MGMT family protein -
P1837_RS17955 (3640739) 3640739..3641308 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T276220 WP_001280991.1 NZ_CP121295:3636315-3636533 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT276220 WP_000344807.1 NZ_CP121295:3635913-3636287 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References