Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1250016..1250830 Replicon chromosome
Accession NZ_CP121295
Organism Salmonella enterica subsp. enterica strain KKP 998

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag P1837_RS05935 Protein ID WP_000971655.1
Coordinates 1250016..1250543 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag P1837_RS05940 Protein ID WP_000855694.1
Coordinates 1250540..1250830 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1837_RS05915 (1245220) 1245220..1247787 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
P1837_RS05920 (1247946) 1247946..1248466 + 521 Protein_1146 cytoplasmic protein -
P1837_RS05925 (1248637) 1248637..1249293 - 657 WP_000420459.1 protein-serine/threonine phosphatase -
P1837_RS05930 (1249520) 1249520..1249943 + 424 Protein_1148 transposase -
P1837_RS05935 (1250016) 1250016..1250543 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
P1837_RS05940 (1250540) 1250540..1250830 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
P1837_RS05945 (1251099) 1251099..1251299 - 201 Protein_1151 IS3 family transposase -
P1837_RS05950 (1251540) 1251540..1251866 + 327 WP_076737359.1 hypothetical protein -
P1837_RS05955 (1252139) 1252139..1252486 - 348 WP_001555786.1 DUF1493 family protein -
P1837_RS05960 (1252471) 1252471..1252920 - 450 WP_000381613.1 hypothetical protein -
P1837_RS05965 (1253352) 1253352..1253795 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
P1837_RS05970 (1254251) 1254251..1254901 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1249749..1249943 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T276215 WP_000971655.1 NZ_CP121295:c1250543-1250016 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT276215 WP_000855694.1 NZ_CP121295:c1250830-1250540 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References