Detailed information of TA system TA276213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1032042..1033740
• Replicon: chromosome
• Accession: NZ_CP121295
• Organism: Salmonella enterica subsp. enterica strain KKP 998

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: P1837_RS04885
• Protein ID: WP_076737406.1
• Coordinates: 1032042..1032971 (-)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: P1837_RS04890
• Protein ID: WP_176202033.1
• Coordinates: 1032958..1033740 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P1837_RS04875 (1027371)	1027371..1030658	+	3288	WP_076737408.1	ATP-binding protein	-
P1837_RS04880 (1030660)	1030660..1031817	+	1158	WP_076737407.1	DUF3322 domain-containing protein	-
P1837_RS04885 (1032042)	1032042..1032971	-	930	WP_076737406.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
P1837_RS04890 (1032958)	1032958..1033740	-	783	WP_176202033.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
P1837_RS04895 (1033889)	1033889..1034758	+	870	WP_076737405.1	hypothetical protein	-
P1837_RS04900 (1034799)	1034799..1035593	+	795	WP_076737404.1	hypothetical protein	-
P1837_RS04905 (1035676)	1035676..1036644	-	969	WP_232234240.1	DUF3644 domain-containing protein	-
P1837_RS04910 (1036769)	1036769..1036915	-	147	WP_232234239.1	hypothetical protein	-
P1837_RS04915 (1037488)	1037488..1037950	+	463	Protein_950	hypothetical protein	-
P1837_RS04920 (1037953)	1037953..1038168	+	216	WP_076737724.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1009131..1038168	29037

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-261)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35094.43 Da
• Isoelectric Point: 6.3527

>T276213 WP_076737406.1 NZ_CP121295:c1032971-1032042 [Salmonella enterica subsp. enterica]
MDLRDSYARQVRLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKAYADRDTDLATINDALMRITESLNGR
PGITAIRQENKADEKRIIVNTADAQIKIEVSPVWRGLLLPATEMPVCEQVEMEYGFTTMNVVSQADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPIAELLAPNWDTSRIATLYAQEFSGMTQRETSLESLLSVTTLLPQTL
KSHLTDRDRQFLLSYKQITPDWSLYRYPEIQHLPAIRWKLRNLAVLKEKNPAKYAATVNKLEGVLEQYF

Nucleotide

• Length: 930 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29289.47 Da
• Isoelectric Point: 7.8227

>AT276213 WP_176202033.1 NZ_CP121295:c1033740-1032958 [Salmonella enterica subsp. enterica]
MPNYLNWLMQNTQPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSAMFVTLYTSGLTVDVTPFTTTLNIGDRQLTGSVPELAAYEIA
GGVPSLISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVMLYLARRNEHPYFRYLDQSDIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp