Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3842456..3842981 Replicon chromosome
Accession NZ_CP121294
Organism Escherichia coli O155:H21 strain NWU_1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag P9N54_RS18555 Protein ID WP_029305600.1
Coordinates 3842456..3842761 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag P9N54_RS18560 Protein ID WP_000813634.1
Coordinates 3842763..3842981 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9N54_RS18540 (3839033) 3839033..3840004 - 972 WP_000817031.1 ParB/RepB/Spo0J family plasmid partition protein -
P9N54_RS18545 (3840004) 3840004..3841170 - 1167 WP_000772446.1 plasmid-partitioning protein SopA -
P9N54_RS18550 (3841769) 3841769..3842455 - 687 WP_072301646.1 tyrosine-type recombinase/integrase -
P9N54_RS18555 (3842456) 3842456..3842761 - 306 WP_029305600.1 type II toxin-antitoxin system toxin CcdB Toxin
P9N54_RS18560 (3842763) 3842763..3842981 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
P9N54_RS18565 (3843561) 3843561..3844649 + 1089 WP_000952217.1 transcriptional repressor PifC -
P9N54_RS18570 (3844651) 3844651..3846876 + 2226 WP_040073691.1 P-loop NTPase fold protein -
P9N54_RS18575 (3846926) 3846926..3847825 - 900 WP_000963206.1 nucleotide-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3807814..3853704 45890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11716.55 Da        Isoelectric Point: 6.4674

>T276206 WP_029305600.1 NZ_CP121294:c3842761-3842456 [Escherichia coli O155:H21]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVPVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT276206 WP_000813634.1 NZ_CP121294:c3842981-3842763 [Escherichia coli O155:H21]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References