Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3798670..3799295 Replicon chromosome
Accession NZ_CP121294
Organism Escherichia coli O155:H21 strain NWU_1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P9N54_RS18265 Protein ID WP_000911317.1
Coordinates 3798897..3799295 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag P9N54_RS18260 Protein ID WP_000450532.1
Coordinates 3798670..3798897 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P9N54_RS18260 (3798670) 3798670..3798897 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
P9N54_RS18265 (3798897) 3798897..3799295 + 399 WP_000911317.1 type II toxin-antitoxin system VapC family toxin Toxin
P9N54_RS18270 (3799304) 3799304..3801457 - 2154 WP_023568632.1 type IV conjugative transfer system coupling protein TraD -
P9N54_RS18275 (3801709) 3801709..3802440 - 732 WP_000850430.1 conjugal transfer complement resistance protein TraT -
P9N54_RS18280 (3802472) 3802472..3802969 - 498 WP_000605859.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T276202 WP_000911317.1 NZ_CP121294:3798897-3799295 [Escherichia coli O155:H21]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT276202 WP_000450532.1 NZ_CP121294:3798670-3798897 [Escherichia coli O155:H21]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References